Patents

Baskin School of Engineering Patent Awardees since June 2016

Practical Two-Frame 3D+2D TV

James Davis
Professor
Computer Science

Awardees: James Davis, Professor of Computer Science

Department: Computer Science

This patent describes a method for making 3D televisions and movie screens viewable without special glasses. These screens currently require viewers to wear special glasses to see the 3D effect. If the glasses are removed then the viewer sees a double image which is essentially unwatchable. The method described here instead provides a normal 2D viewing experience when the glasses are removed.

Link to patent

Robust Single-Phase DC/AC Inverter for Highly Varying DC Voltages

Ricardo Sanfelice, Associate Professor Computer EngineeringRicardo Sanfelice
Associate Professor
Computer Engineering

Awardees:      Ricardo Sanfelice,   Associate   Professor   Computer   Engineering;  Jun Chai, Research Assistant

Department: Computer Engineering

The invention provides a single phase DC/AC inverter with a unique hybrid control circuit. Given an input DC voltage signal, the inverter produces an AC output signal that approximates a given sinusoidal AC reference signal. The invention solves the problem of robustly converting highly varying DC power into desired AC power. Advantageously, the precision with which the AC output signal approximates a desired reference signal can be adjusted via a tunable parameter in the control circuit, conversion is guaranteed under varying input voltages, and the harmonic distortion is almost entirely eliminated at low frequencies.

Link to patent

Current Mode Clock Distribution

Matthew Guthaus, Associate Professor Computer EngineeringMatthew   Guthaus
Associate Professor 
Computer Engineering

Awardees:     Matthew   Guthaus,   Associate   Professor   Computer   Engineering;  Riadul Islam (previously PhD Student at UCSC)

Department: Computer Engineering

In a high-performance computer system design, the clock network consumes a significant amount of power and causes the most switching noise. High power consumption requires larger batteries while switching noise degrades the accuracy of sensitive sensor measurements in modern Systems-on-Chips. Prof. Matthew Guthaus, faculty in Computer Engineering, and his graduate student Riadul Islam, now a faculty at University of Michigan Dearborn, have developed the concept of a current-mode clock distribution to address these problems. Current-mode clocking senses current flow rather than a traditional voltage swing in clock wires and thereby eliminates most of the noise and power problems in traditional clock distribution schemes. Current-mode clocking simultaneously increases the potential maximum speeds of computer chips for performance improvements.

Link to patent

Therapeutic Compositions And Methods For Treating HIV Including Identification And Manipulation Of Particular Domains Associated With Immunogenicity

Phillip Berman, Distinguished ProfessorPhillip   Berman
Distinguished Professor
Biomolecular Engineering
Sara O'RourkeSara O'Rourke, Associate Project Scientist

Awardees: Phillip Berman, Distinguished Professor; Sara O’Rourke, Associate Project Scientist; William Scott, Professor

Department: Biomolecular Engineering

This patent describes HIV viral proteins with engineered mutations. In particular, the engineered mutations help expose antibody epitopes in the viral proteins that raise broadly neutralizing antibody responses, which could in turn result in a more effective HIV vaccine.

HIV-1 Gp 120 V1n2 Antigens And Immunological Uses Thereof

Awardees: Phillip Berman, Distinguished Professor; Kate Mesa, Lab Manager; Bin Yu, Specialist

Department: Biomolecular Engineering

This patent describes small, properly folded and glycosylated fragments of the HIV envelope glycoprotein, gp120, that appear to be useful components of an HIV vaccine. Over the last decade scientists have identified 3-4 sites on the 510 amino acid envelope protein recognized by protective antibodies. However these sites contain specific sugar molecules (mannose-5) and fail to promote a strong immune responses in the context of the full length gp120 molecule. Thus new ways are required to target antibody responses to these key sites rather than the dozen or more sites recognized by non-protective antibodies. This patent describes properly folded and glycosylated fragments of gp120, and methods for their production. When included in an HIV vaccine, these fragments can focus the immune response to sites recognized by protective antibodies.

Link to patent

Switchable LED Lightbulb

Awardee: David Munday, Lecturer

Department: Computer Engineering

The US patent office recently issued a patent to a senior design student team and Professor David Munday for inventing a new LED lightbulb capable of multiple brightness settings all within the same bulb. Most commercial LED light bulbs are manufactured for a given brightness level, but this bulb is adjustable through a number of possible controls including onboard buttons, wifi control, and automatic brightness control.

Link to Patent

Two-Chambered Dual-Pore Device

Holger Schmidt, Associated Dean for ResearchHolger Schmidt, Associate Dean for Research and Professor of Electrical Engineering 

Awardee: Holger Schmidt, Associate Dean for Research and Professor of Electrical Engineering 

Department: Electrical Engineering

Nanopores form the basis of several approaches to next generation DNA sequencing technology. The basic idea behind this is to identify the bases that make up DNA one by one as they move through a nanoscopic opening. This invention describes how to improve control over the molecules to be tested by using two coupled nanopores, and how to implement this principle on a compact semiconductor chip.

 

Link to patent

BamBam: Parallel Comparative Analysis of High-Throughput Sequencing Data

David Haussler, Distinguished ProfessorDavid Haussler, Distinguished Professor, Biomolecular Engineering

Awardee: David Haussler, Distinguished Professor and Scientific Director, UC Santa Cruz Genomics Institute

Department: Biomolecular Engineering

The purpose of this invention is to more efficiently compare biological sequences from two distinct samples. The analysis of biological sequence information usually involves the manipulation of enormous data files, which in turn results in long processing times to generate a meaningful comparison between the biological sequences. The inventions described in these two patents provides a more efficient way to compare biological sequences from distinct samples from a patient (e.g. normal tissue vs. tumor tissue) and generate patient-specific treatment instructions based on those sequences.

Link to patent

BamBam: Parallel Comparative Analysis of High-Throughput Sequencing Data (two patents)

David Haussler, UC Santa Cruz Genomics InstituteDavid Haussler, Distinguished Professor, Biomolecular Engineering

Awardee: David Haussler, Distinguished Professor and Scientific Director, UC Santa Cruz Genomics Institute

Department: Biomolecular Engineering

The purpose of the inventions encompassed by these two patents is to more efficiently compare biological sequences from two distinct samples. The analysis of biological sequence information usually involves the manipulation of enormous data files, which in turn results in long processing times to generate a meaningful comparison between the biological sequences. The inventions described in these two patents provides a more efficient way to compare biological sequences from distinct samples from a patient (e.g. normal tissue vs. tumor tissue) and generate patient-specific treatment instructions based on those sequences. The 9,646,134 patent concerns genomic information while the 9,652,587 patent also encompasses proteomic and transcriptomic information.

Link to patent 1

Link to patent 2

 

Interferometric focusing of guide-stars for direct wavefront sensing

Joel Kubby, Professor of Electrical EngineeringJoel Kubby, Professor of Electrical EngineeringXiadong Tao, Assistant Project Scientist — Electrical EngineeringXiadong Tao, Assistant Project Scientist, Electrical Engineering

Awardees: Joel Kubby, Professor; Xiaodong Tao, Assistant Project Scientist

Department: Electrical Engineering

The optimal performance of an optical microscope is difficult to achieve due to aberrations caused by tissues. In order to compensate for these aberrations, we applied adaptive optics with direct wavefront sensing using fluorescent "guide-stars" embedded in tissues for wavefront measurement. A scattering effect within the tissues limits the intensity of the guide star and reduces the signal to noise ratio of wavefront measurement. This patent describes the use of interferometric focusing of excitation light onto a guide-star deep within tissue to increase the fluorescence intensity of the guide-star which in turn overcomes the signal loss caused by scattering.

Link to patent

Nanopipette Apparatus for Manipulating Cells

Nader Pourmand, Associate Professor of Biomolecular EngineeringNader Pourmand, Associate Professor of Biomolecular Engineering

Awardee: Nader Pourmand, Associate Professor

Department: Biomolecular Science and Engineering

The ability to study the molecular biology of living single cells in heterogeneous cell populations is essential for next generation analysis of cellular circuitry and function. Dr. Pourmand and his team have developed a single-cell interrogation platform based on scanning ion conductance microscopy for continuous sampling of intracellular content from individual cells. Among many other functionalities, for the nanobiopsy, this platform uses a nanopipette to extract cellular material from living cells with minimal disruption of the cellular milieu. Researchers might use this platform to understand cancer and other diseases which might provide a foundation for dynamic subcellular genomic analysis.

Link to patent

Compositions, Devices, Systems, And Methods For Using A Nanopore

Mark Akeson, professor of Biomolecular EngineeringMark Akeson, Professor of Biomolecular Engineering

Awardee: Mark Akeson, Professor

Department: Biomolecular Science & Engineering

The invention is one of a series of patents from the biomolecular engineering department concerning sequencing of DNA using a nanoscale hole or "nanopore." When a voltage is applied across the nanopore, DNA is pulled through the hole in single file order. The bases that make up the DNA are read as they transit the pore. In this particular patent, the inventors combined voltage feedback control with an enzyme to precisely regulate movement of the DNA. This results in improved DNA sequencing accuracy.

Faster, Better Genome Assembly

Ed Green's startup, Dovetail Genomics,  opened its doors in summer 2013 in a bio-incubator space on campus, and now employs about 20 people in its own office in Santa Cruz. (Photo by Steve Kurtz)Ed Green's startup, Dovetail Genomics, opened its doors in summer 2013 in a bio-incubator space on campus, and now employs about 20 people in its own office in Santa Cruz. (Photo by Steve Kurtz)

Awardee: Edward Green, Associate Professor

Department: Biomolecular Engineering

Assembling genomes is like solving a giant, 3 billion-piece jigsaw puzzle. The invention describes a streamlined way to figure out which pieces are near other pieces so the puzzle can be reconstructed more accurately and quickly. Licensed by Dovetail Genomics in Santa Cruz, the invention has been used to assemble the genomes of hundreds of plant and animals. With this information, scientists can begin to unravel the biology inherent in each.

In the spring, several new initiatives from the UC Office of the President will be rolled out across the 10 campuses to further innovation, commercialization, and entrepreneurship and highlight the growing body of research providing public benefit. The IATC office will lead the implementation of these initiatives with various leaders around campus to bring these opportunities to the entire university community.

Link to patent