Noller group solves ribosomal structure by x-ray crystallography

Friday, May 4, 2001

Harry Noller's group recently solved the x-ray crystallographic structure of 70S ribosome functional complexes, first at 7.8 angstrom resolution, then at 5.5 angstrom resolution. These views of ribosome functional complexes are major advances, supporting the model that ribosome function, including the mechanisms of tRNA binding, peptide bond formation, and translocation of tRNA and mRNA within the ribosome, is based on RNA function. This work was were reported as cover stories in the journal Science on September 24 1999 (pages 2095-104) and on May 4 2001 (pages 883-96).