Noise Attenuation in Biological Systems

Speaker Name: 
Dr. Qing Nie, Professor, Dept. of Mathematics, Dept. of Biomedical Engineering, UC Irvine
Start Time: 
Monday, April 4, 2011 - 4:00pm
End Time: 
Monday, April 4, 2011 - 5:00pm
Location: 
Engineering 2, Room 180
Organizer: 
Assistant Professor Qi Gong

Abstract

In this talk, we will first introduce a new quantity called Signed Activation Time (SAT), which is found to be critical in determining noise attenuation capability of a feedback system. We will next study how noise amplification rates of several biological examples may depend on SAT and investigate strategies for noise attenuation in systems involving both extra-cellular and intra-cellular components. In particular, we will study boundary sharpening during Zebrafish embryonic development.

Biography

Qing Nie is a professor of Mathematics and Biomedical Engineering at University of California at Irvine (UCI). Currently, Dr. Nie is the acting director of a campus-wide interdisciplinary Ph.D. gateway program on mathematical and computational biology and the director of Center for Mathematical and Computational Biology at UCI. Dr. Nie is also a theme and core leader for UCI Center for Complex Biological Systems – a national center of excellence on systems biology funded by NIH. Dr. Nie was a Chancellor Fellow from 2005 to 2008. Before joining UC as an assistant professor in 1999, Dr. Nie was an instructor at University of Chicago. Dr. Nie obtained Ph.D. in Mathematics at The Ohio State University in 1995. Dr. Nie’s current research interests include computational systems biology, stem cells, cell signaling, and morphogenesis.