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Defense: Nano-Opto-Mechanical Tools for Multiscale Biomedical Applications: From Exosomes to Rare Cells

Speaker Name: 
Xiangchao (Jude) Zhu
Speaker Title: 
PhD Candidate (Advisor: Ali Yanik)
Speaker Organization: 
Electrical Engineering
Start Time: 
Thursday, May 30, 2019 - 10:00am
End Time: 
Thursday, May 30, 2019 - 12:00pm
Engineering 2, Room 280
Ali Yanik

Absctract:  We are living in an exciting era of a fast-paced confluence of wide-ranging research fields and emerging technological breakthroughs that are profoundly altering our biomedical practices. In particular, the marriage of micro-nanotechnology and biotechnology is propelling our technical capabilities to new horizons. Despite tremendous progress and innovation made over the past 20 years, efforts are still needed to overcome fundamental physiological and technological barriers at different length scales spanning from few nanometers to tens of microns. This thesis presents (1) an innovative and low-cost acousto-microfluidic approach enabling highly efficient and selective low-abundance in vitro cell isolation, (2) a novel visible light-activated therapeutic nanophotonic platform for combating drug-resistant bacterial pathogens (vibrio cholerae), and (3) a unique nanophotonic platform offering a scalable separation and selective enrichment capability for exosomes based on size and chemical composition.