Advancement: Tools for large and detailed experiments in genomics and tissue development

Speaker Name: 
Yohei Rosen
Speaker Title: 
PhD Student
Speaker Organization: 
Biomolecular Engineering & Bioinformatics
Start Time: 
Wednesday, June 13, 2018 - 2:00pm
End Time: 
Wednesday, June 13, 2018 - 4:00pm
Location: 
Physical Sciences, Room 305
Organizer: 
David Haussler and Benedict Paten

Abstract:  Computational genomics and neural tissue development are two fields which may benefit more realistic models and the ability to analyze more experimental units.

Two active areas of genomic research are graph structures to represent complex differences between genomes and algorithms which allow us to include larger subsets of the population in our analyses. I have worked on decomposing graph genome representations into fundamental topological units analogous to genetic sites. I have also worked on algorithm designs which make certain haplotype analysis algorithms tractable on very large data sets.

In terms of engineering for biology, I will discuss my work on building more anatomically accurate cerebral organoid models of brain development. I will also discuss technologies which will allow highly parallel automated maintenance, observation and experimentation using these organoids or other tissue models.