Advancement: Integrated system for three-dimensional cell culture monitoring and stimulation

Speaker Name: 
Pattawong Pansodtee
Speaker Title: 
PhD Candidate
Speaker Organization: 
Computer Engineering
Start Time: 
Friday, August 16, 2019 - 12:00pm
End Time: 
Friday, August 16, 2019 - 2:00pm
Engineering 2, Room 599
Mircea Teodorescu

Abstract:  Organoids are self-organized in-vitro three-dimensional tissue cultures that are derived from stem cells. Such cultures can be crafted to replicate much of the complexity of an organ tissue, or to express selected aspects of it like producing only certain types of cells. Scientists have learned how to create a somehow right environment for the stem cells so they can follow their own genetic instructions to self-organize. However, a major limitation in organoids research and development has been the abilities to maintain organoid growth into reasonable tissue size. In vivo, developing tissues are interpenetrated by and interact with a complex network of vasculature which allows not only oxygen, nutrient and waste exchange, but also provide for inductive biochemical exchange and a structural template for growth. We need to replicate this process in-vitro. The purpose of this work is to create a system that promotes in-vitro Organoid growth. To enable this system to work effect! ively, the work must be preceded by a model of organoid growth. In summary, in this work I propose an integrated in-incubator sensing and monitoring system as well as a predictive mathematical model for Organoid development.