All Events

Mar 7

Transcriptional Regulation of the Hemogenic Endothelium

Carlos Lizama
Postdoctoral Scholar

Hematopoietic stem cells (HSC) are generated during embryogenesis from specialized vascular beds termed hemogenic endothelium (HE), including the aortic endothelium of the aortic-gonado-mesonephros (AGM) region. In the aorta, pre-HSCs are organized in clusters attached to the vascular endothelium.... Read More

Mar 6

Ontogeny and plasticity of the lung stem cell pool in development and disease

Wellington V. Cardoso, MD, PhD
Professor of Medicine and Genetics and Development Director, Columbia Center for Human Development

Abstract: Tissue-specific stem cells are crucial in maintaining homeostasis and integrity of adult organs. In the conducting airways of the lung, these cells occupy the basal compartment of the epithelium and give rise to multiple differentiated cell types. Under persistent injury by environmental... Read More

Mar 4

Stem cell dynamics in intestinal and biliary epithelia

Adam Gracz
Assistant Professor, Department of Genetics & Center for Gastrointestinal Biology and Disease

Abstract Our lab is interested in understanding the role of chromatin in regulating stem cell function, including self-renewal, differentiation, and plasticity, in the intestinal epithelium. To do this, we use a Sox9EGFP transgenic reporter mouse, which allows us to differentially isolate stem... Read More