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Applied mathematics and statistics are disciplines devoted to the use of mathematical methods and reasoning to solve real-world problems of a scientific or decision-making nature in a wide variety of subjects, principally (but not exclusively) in engineering, medicine, the physical and biological sciences, and the social sciences. Applied mathematical modeling often involves the use of systems of (partial) differential equations to describe and predict the behavior of complex real-world systems that unfold dynamically in time. Statistics, construed broadly, is the study of uncertainty: how to measure it (using ideas and methods in probability theory), and what to do about it (using concepts from statistical inference and decision theory).