Human vs. Mouse
Chromosomes substantially rearranged, though large areas of synteny persist.
In regions with no positive selection close to 50% of bases have mutated.
Inside protein coding regions only about 10% of amino acids have mutated.
Mutation rate is nearly double in rodent lineage compared to human lineage.
Single copy genes similar, gene families diverged.
Most organs (heart, liver, kidneys, etc) near identical with humans.