[Genome] Gene Order in primates
Subhajyoti De
sde at mrc-lmb.cam.ac.uk
Thu Jan 3 09:42:31 PST 2008
Hi,
Greetings of new year. I have a naive question to ask about genome
assembly and gene order in chimpanzee and macaque.
I have a list of a few human genes, whose orthologs (or homologs)
in chimpanzee and macaque are located at different chromosomal
locations, while orthologs of most of the neighboring genes still
maintain synteny. For example, a gene is located in human chromosome 12.
It has one ortholog in chimpanzee and that is located in chimp
chromosome 18 (and no paralog or pseudogene is present at position
equivalent to that in human chromosome 12). Many such cases are
biologically known, driven by short rearrangements or retrotransposon
mediated activities, while a small number of others can appear due to
errors in genome assembly.
Can you kindly give me a rough estimate, how many such cases of
altered gene order I can expect in the current release of chimpanzee and
macaque genome due to assembly error and/or coverage?
Many thanks,
Subho
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