[Genome] Gene Order in primates

Subhajyoti De sde at mrc-lmb.cam.ac.uk
Thu Jan 3 09:42:31 PST 2008


Hi,

   Greetings of new year. I have a naive question to ask about genome 
assembly and gene order in chimpanzee and macaque.

     I have a list of a few human genes, whose orthologs (or homologs) 
in chimpanzee and macaque are located at different chromosomal 
locations, while orthologs of most of the neighboring genes still 
maintain synteny. For example, a gene is located in human chromosome 12. 
It has one ortholog in chimpanzee and that is located in chimp 
chromosome 18 (and no paralog or pseudogene is present at position 
equivalent to that in human chromosome 12). Many such cases are 
biologically known, driven by short rearrangements or retrotransposon 
mediated activities, while a small number of others can appear due to 
errors in genome assembly.

    Can you kindly give me a rough estimate, how many such cases of 
altered gene order I can expect in the current release of chimpanzee and 
macaque genome due to assembly error and/or coverage?

Many thanks,
Subho


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