[Genome] Dog

[Dawn R. Applegate, Ph.D.]

Thanks Kayla and Hiram. I will research the information you provided.

Dawn 
-----Original Message-----
From: Kayla Smith [mailto:kayla at soe.ucsc.edu] 
Sent: Tuesday, April 15, 2008 11:16 AM
To: Dawn R. Applegate, Ph.D.
Cc: genome at soe.ucsc.edu
Subject: Re: [Genome] Dog


Hello Dawn,

I can point you in the direction of some resources which may be useful 
to you.

The gateway page for our dog browser (canFam2) has information on where 
we got the sequence from:
http://genome.ucsc.edu/cgi-bin/hgGateway?clade=vertebrate&org=Dog&db=0

Broad has information on dog sequencing and dog snps:
http://www.broad.mit.edu/mammals/dog/

I hope this helps to get you started.  Unfortunately I don't know any 
scientists to connect you with.

Kayla Smith
UCSC Genome Bioinformatics Group



Dawn R. Applegate, Ph.D. wrote:
> Dear Dr. Kent and the Genome Bioinformatics Group:
> 
> With respect to your dog database on genome browser, can you connect me
with
> scientists who have contributed/are expert in SNP analysis of dogs, with
> special emphasis on Beagle and Dalmatian breeds? I have done a partial
liver
> transplant of Beagle liver into Dalmatian dogs and want to monitor the
> persistence of Beagle liver in the Dalmatian dog. The catch s the study
was
> initiated 15 years ago and the company who performed the work is out of
> business so we do not have a liver sample from the Beagles from which the
> original liver tissue for transplantation was derived. I don't know if the
> genetic 'constancy' of Beagles is known such that we can assume a Beagle
is
> a Beagle is a Beagle throughout the last 20 years. I would suppose the use
> of a broader SNP panel differentiating Beagle from Dalmatian would be
> required to unequivocally prove the Beagle tissue remains (now 15 years
> post-transplant). We have monitored the biological outcome of the single
> gene defect correction and it is still present. I just want definitive
proof
> the Beagle cells are still present. The differentiation could also be
based
> on the Dalmatian single gene defect, demonstrating that the defect is
absent
> in the Beagle cells.
> 
>  
> 
> I am expert in tissue engineering and gene expression profiling, not
> genotyping. Hence, I'll grow you a new liver to treat the impact of your
> Saturday bar hopping in exchange for assistance! 
> 
>  
> 
> Looking forward to you reply.
> 
> Dawn
> 
>  
> 
> Dawn R. Applegate, Ph.D.
> 
> President & CEO
> RegeneMed, Inc.
> 
> 9855 Towne Centre Drive
> 
> Suite 200
> 
> San Diego, CA 92121
> 
> (858) 200-9529 direct
> 
> (858) 200-9530 office
> 
> (858) 200-9531 fax
> 
> (619) 200-0412 mobile
> 
> dapplegate at regenemed.com 
> 
> dapplegate at alum.mit.edu
> 
> www.RegeneMed.com 
> 
>  
> 
> _______________________________________________
> Genome maillist  -  Genome at soe.ucsc.edu
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