[Genome] Dog

[Hiram Clawson]

Good Morning Dawn:

In addition to the resources that Kayla mentioned, you may also
be interested in the extensive dog genome research at NHGRI:
	http://research.nhgri.nih.gov/dog_genome/
and:	http://research.nhgri.nih.gov/dog_genome/info_for_dog_owners/index.shtml

--Hiram

> Dawn R. Applegate, Ph.D. wrote:
>> Dear Dr. Kent and the Genome Bioinformatics Group:
>>
>> With respect to your dog database on genome browser, can you connect me with
>> scientists who have contributed/are expert in SNP analysis of dogs, with
>> special emphasis on Beagle and Dalmatian breeds? I have done a partial liver
>> transplant of Beagle liver into Dalmatian dogs and want to monitor the
>> persistence of Beagle liver in the Dalmatian dog. The catch s the study was
>> initiated 15 years ago and the company who performed the work is out of
>> business so we do not have a liver sample from the Beagles from which the
>> original liver tissue for transplantation was derived. I don't know if the
>> genetic 'constancy' of Beagles is known such that we can assume a Beagle is
>> a Beagle is a Beagle throughout the last 20 years. I would suppose the use
>> of a broader SNP panel differentiating Beagle from Dalmatian would be
>> required to unequivocally prove the Beagle tissue remains (now 15 years
>> post-transplant). We have monitored the biological outcome of the single
>> gene defect correction and it is still present. I just want definitive proof
>> the Beagle cells are still present. The differentiation could also be based
>> on the Dalmatian single gene defect, demonstrating that the defect is absent
>> in the Beagle cells.
>>
>> I am expert in tissue engineering and gene expression profiling, not
>> genotyping. Hence, I'll grow you a new liver to treat the impact of your
>> Saturday bar hopping in exchange for assistance! 
>>
>> Looking forward to you reply.
>>
>> Dawn R. Applegate, Ph.D.
>>
>> President & CEO
>> RegeneMed, Inc.
>> 9855 Towne Centre Drive
>> Suite 200
>> San Diego, CA 92121
>>
>> (858) 200-9529 direct
>> (858) 200-9530 office
>> (858) 200-9531 fax
>> (619) 200-0412 mobile
>>
>> dapplegate at regenemed.com 
>> dapplegate at alum.mit.edu
>> www.RegeneMed.com