[Genome] Dog

[Dawn R. Applegate, Ph.D.]

Dear Dr. Kent and the Genome Bioinformatics Group:

With respect to your dog database on genome browser, can you connect me with
scientists who have contributed/are expert in SNP analysis of dogs, with
special emphasis on Beagle and Dalmatian breeds? I have done a partial liver
transplant of Beagle liver into Dalmatian dogs and want to monitor the
persistence of Beagle liver in the Dalmatian dog. The catch s the study was
initiated 15 years ago and the company who performed the work is out of
business so we do not have a liver sample from the Beagles from which the
original liver tissue for transplantation was derived. I don't know if the
genetic 'constancy' of Beagles is known such that we can assume a Beagle is
a Beagle is a Beagle throughout the last 20 years. I would suppose the use
of a broader SNP panel differentiating Beagle from Dalmatian would be
required to unequivocally prove the Beagle tissue remains (now 15 years
post-transplant). We have monitored the biological outcome of the single
gene defect correction and it is still present. I just want definitive proof
the Beagle cells are still present. The differentiation could also be based
on the Dalmatian single gene defect, demonstrating that the defect is absent
in the Beagle cells.

 

I am expert in tissue engineering and gene expression profiling, not
genotyping. Hence, I'll grow you a new liver to treat the impact of your
Saturday bar hopping in exchange for assistance! 

 

Looking forward to you reply.

Dawn

 

Dawn R. Applegate, Ph.D.

President & CEO
RegeneMed, Inc.

9855 Towne Centre Drive

Suite 200

San Diego, CA 92121

(858) 200-9529 direct

(858) 200-9530 office

(858) 200-9531 fax

(619) 200-0412 mobile

dapplegate at regenemed.com 

dapplegate at alum.mit.edu

www.RegeneMed.com