[Genome] FW: Could you please answer me another question

[Heather Trumbower]

Hi again Brad:

I looked at Il12B in our browser.   It is located in the region 
chr5:158,674,000-158,691,000.   I zoomed in to what I thought might be the 
promoter region at chr5:158,685,000-158,697,000.   I filtered the SNPs (126) 
track to show only insertions and deletions.

I am wondering whether rs17860508 might be the in-del you are looking for.
The reference sequence has TTAGAG (the reverse complement of the allele you 
mention) at this location.  The dbSNP details page at
http://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs17860508
also reports a GC allele.

I hope our tools can help you, this is a tricky thing to work out.
Let us know if you have further questions.

Heather Trumbower
UCSC Genome Bioinformatics Group


> On Wed, 25 Jul 2007, Brad Zhang wrote:
> 
>> Dear All,
>> Anyone can answer me a question? I am not an expert in genetics.
>> Attached please find a paper in which a SNP(?) in the promoter was
>> reported in IL12B gene in Human. There are several studies that
>> investigated the SNP. I reckon it should be found in the UCSC website or
>> others. But I do not know how to find this one.
>> 
>> The SNP has two alleles: allele 1: CTCTAA; allele 2: GC
>> 
>> Could you please tell me how to find the SNP? Like that SNP, it should
>> have an rsnumber for it?
>> 
>> Thank you very much.
>> 
>> Brad.
>> 
>