[Genome] Incorrectly annotated link

[Michael A. Cahill]

Dear Sir/Madam,

I would like to report an error in your bioinformatics 'UCSC Proteome
Browser' server for the entry of Protein O00264 (aka PGRC1_HUMAN or
PGC1_HUMAN) Membrane associated progesterone receptor component 1 (mPR).

http://harvester.embl.de/harvester/Q6IB/Q6IB11.htm#PROTEOME

The above page concerns the HGNC protein designated PGRMC1. The
following link is erroneous.

"Pathways: 

BioCarta -  h_mPRPathway
(http://cgap.nci.nih.gov/Pathways/BioCarta/h_mPRPathway) - How
Progesterone Initiates the Oocyte Maturation"

This linked 'mPR' pathway refers to a seven membrane receptor G-coupled
protein also called mPR (membrane progestin receptor), which is NOT the
cytochrome B5-containing Membrane Progesterone Receptor (mPR/PGRMC1).
See the following text from a review I have written on PGRMC1.  

Cahill MA. 2007. Progesterone Receptor Membrane Component 1: an
integrative review. J. Ster. Biochem. Mol. Biol. in press (probably to
appear in the April 2007 edition).

mPR: nomenclatural booby trap
Note that another protein (in addition to mPR/PGRMC1), termed membrane
progestin receptor, has also been denoted as mPR in the literature. This
different gene product is a G-protein coupled seven membrane domain
progestin receptor found from fish to mammals that conveys non-genomic
effects of progesterone, and is otherwise not at all related to PGRMC1
or PR [16]. There are currently eleven mammalian members belonging to
this separate gene family, which has been named the PAQR family, after
two of the initially described ligands (progestin and adipoQ receptors)
[17].

References:
16. Y. Zhu, J. Bond, P. Thomas, Identification, classification, and
partial characterization of
genes in humans and other vertebrates homologous to a fish membrane
progestin receptor,
Proc. Natl. Acad. Sci. U. S. A. 100 (5) (2003) 2237-2242.
17. Y.T. Tang, T. Hu, M. Arterburn, B. Boyle, J.M. Bright, P.C. Emtage,
W.D. Funk, PAQR
proteins: a novel membrane receptor family defined by an ancient
7-transmembrane pass
motif, J. Mol. Evol. 61 (3) (2005) 372-380.


Kind regards,
Mike Cahill.


________________________________________________________
PROTEOSYS AG - Carl-Zeiss-Str 51 - 55129 Mainz - Germany.

Michael Cahill,
Chief Research Officer,
tel: +49(0)61 31-50 192 25.
fax: +49(0)61 31-50 192 11.
www.proteosys.com.