[Genome] Exon conservation

Isabelle Dupanloup isabelle.dupanloup at zoo.unibe.ch
Thu Apr 5 00:15:53 PDT 2007


Hello there,

I'm trying to get some info about exon conservation in mammals (genome
scale).
For example, I would like to know if exons annotated by ENSEMBL in the
human genome are present in the genome of mouse, chimp, etc.

One of your colleagues (Heather) suggested me to use the table browser
to generate a custom track that contains exons 
from gene annotations. Then to use the table browser to intersect the
exons with the Mouse/Chimp chain (from the conservation track).

This is what I did (see screen shots attached). But the output does not
contain anything about exon conservation:

-----------------------
track name="tb_ensGene" description="table browser query on ensGene"
visibility=2 url= 
chrX	119906996	119909329	ENST00000328078	0	+
119907073	119908750	0	1	2333,	0,
-----------------------

Could you help me to solve that problem ?

For me what could be nice is to get orthologous positions of human exons
in the mouse/chimp genome (if they exist) and an indication of the
absence of the human exons in the mouse/chimp genome (if they are not
found in these genomes).

I hope my msg is clear enough.

Thank you very much in advance for your help and your great UCSC tool !

Best, Isabelle

-------------------
Isabelle Dupanloup PhD
Computational and Molecular Population Genetics Group
Baltzerstrasse 6
3012 Bern
Switzerland
Tel: +41 31 631 45 49
Fax: +41 31 631 48 88


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