[Genome] Transcription Factor Binding Site

[????? ???? - Giladi Hilla]

Dear Sir,

I am interested in the human miR-122 microRNA region on chromosome 18.

 

When I searched this region with the UCSC Browser dated May 2004 for transcription factor binding sites, I found a consensus for the binding of the FoxO1, FoxO3 and FoxO4 transcription factors, located approximately 920 bp upstream of miR-122.

 

When I repeated the search with the March 2006 version of the UCSC Browser, these putative TFB sites no longer appear. 

 

I did compare the published consensus binding site (there are several which differ at one position) to the putative one upstream of miR-122 and the match seems good.

 

I would appreciate it if you explain to me what are the guidelines that determine when these sites appear in the browser.

 

Thank You very much in advance

Hilla Giladi

 
 
Hilla Giladi Ph.D
Goldyne Savad Institute of Gene Therapy
Hadassah University Hospital
P.O.Box 12000, Jerusalem, Israel
Tel: 972-2-6777998
Fax: 972-2-6430982




 
 
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