[Genome] ABL2 inconsistency
Mathias Ehrich
MEhrich at sequenom.com
Thu Dec 28 08:51:14 PST 2006
Dear Genome Browser Team,
I am trying to retrieve the transcription start sites for a number of
genes. I have managed to implement the database query using MySQL.
Everything appeared to be working fine, but when I started checking the
results I found a small inconsistency between the website results and
the results obtained by the SQL query. The location of the ABL2 gene
(NM_005158) differs by approximately 2M bp. I'm not sure that I used the
correct versions, but I used 'hg18' for the SQL query and the assembly
'March 2006' for the website. I have attached both results for your
review.
Do you know where this inconsistency is might come from.
Thanks for your help.
Best regards
Mathias Ehrich
Results from MySQL Query
Schema: hg18
Query:
SELECT k.name, k.chrom, k.strand, k.txStart ,k.cdsStart, k.cdsEnd,
k.exonStarts, k.exonEnds
FROM knownGene k
WHERE k.chrom = 'chr1' AND k.strand = '-' AND k.name = 'NM_005158'
Results:
Name, chrom, strand, txStart, cdsStart, cdsEnd
'NM_005158', 'chr1', '-', 175808413, 175808509, 175843836, '', ''
Results from GenomeBrowser Website
Assembly: March 2006
Description: v-abl Abelson murine leukemia viral oncogene
Alternate Gene Symbols: RP11-177A2.3-002
Representative Refseq: NM_005158
<http://genome.ucsc.edu/cgi-bin/hgc?hgsid=83437299&g=refGene&i=NM_005158
&c=chr1&o=177343379&l=177343379&r=177378808&db=hg18> Protein: Q5W0C5
<http://www.expasy.org/cgi-bin/niceprot.pl?Q5W0C5>
RefSeq Summary: ABL2 is a cytoplasmic tyrosine kinase which is closely
related to but distinct from ABL1. The similarity of the proteins
includes the tyrosine kinase domains and extends amino-terminal to
include the SH2 and SH3 domains. ABL2 is expressed in both normal and
tumor cells. The ABL2 gene product is expressed as two variants bearing
different amino termini, both approximately 12-kb in length.
Position: chr1:177343380-177378808
Strand: -
Genomic Size: 35429
Exon Count: 11
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