Associate Professor, Biomolecular Engineering

Baskin School of Engineering
1156 High St
Mail Stop SOE2
Santa Cruz, CA 95064

Phone Number: 831-459-1511

Department: Biomolecular Engineering

Office Location: Physical Sciences Building 316
Office Hours: Monday 1-2pm, Wednesday 11am-Noon, and by email appt.

E-Mail Address:

Web Pages

• Lowe Lab website
• Archaeal Genome Browsers
• Microbial Genome Browsers
• Genomic Transfer RNA Database

Degrees

• B.A in Biology, 1992, Williams College, Williamstown MA
• Ph.D. in Molecular Genetics, 1999, Washington Univ. in St. Louis

Research Areas

Experimental and computational genomics, non-coding RNA gene finders, high-throughput small RNA sequencing, small RNA roles in cancer, evolution of RNA-based gene regulation

Selected Publications

• Bernick, D.L., Dennis, P.P., Hochsmann, M. and Lowe, T.M. (2012) Discovery of Pyrobaculum small RNA families with atypical pseudouridine guide RNA features. RNA, 18, 402-411.
• Chan, P.P., Cozen, A.E. and Lowe, T.M. (2011) Discovery of permuted and recently split transfer RNAs in Archaea. Genome biology, 12, R38.
• Lai, L.B., Chan, P.P., Cozen, A.E., Bernick, D.L., Brown, J.W., Gopalan, V. and Lowe, T.M. (2010) Discovery of a minimal form of RNase P in Pyrobaculum. Proc Natl Acad Sci U S A, 107, 22493-22498.
• Chan, P.P., Holmes, A.D., Smith, A.M., Tran, D. and Lowe, T.M. (2012) The UCSC Archaeal Genome Browser: 2012 update. Nucleic Acids Res, 40, D646-652.
• Cozen, A.E., Weirauch, M.T., Pollard, K.S., Bernick, D.L., Stuart, J.M. and Lowe, T.M. (2009) Transcriptional map of respiratory versatility in the hyperthermophilic crenarchaeon Pyrobaculum aerophilum. J Bacteriol, 191, 782-794.

Current and Future Classes

Spring 2012

• BME 110: Computational Biology Tools
• BME 281L: Seminar in Computational Genetics

Fall 2012

• BME 110: Computational Biology Tools
• BME 280B: Seminar on Bioinformatics
• BME 281L: Seminar in Computational Genetics

Students & Researchers

• Patricia Chan (Researcher)
• Aaron Cozen (Researcher)
• Andrew Holmes (Graduate)
• Lauren Lui (Graduate)
• Tim Sterne-Weiler (Graduate)
• Andrew Uzilov (Graduate)

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