BME280b Spring 2007 Schedule
Class time and location:
Thursdays, 12:00 noon - 1:45pm (max) - in PSB305 unless announced otherwise.
First class meeting:
Thursday April 5
Instructor/Coordinator:
Dietlind Gerloff
(office: PSB320 - send email)
Refereeing Exercise (May 23-end of quarter):
This quarter, BME280B consists of a mix of invited talks by bioinformatics researchers, and paper discussions - in which you will get more familiar with refereeing papers. As you know the judgment, and input, of referees is vital to scientific publishing. More and more refereeing is done by junior scientists (grad students and postdocs) - one of the learning goals for this run of 280B is to provide you with a bit of practice in this area... alongside hearing about recent relevant research in our field.
FORMS etc:
* Referee form (.doc)
Notes:
-
Unfortunately there is still a small problem with accessing the
large version of the figures in Paper1 - at present this is probably only
possible from campus-computers (I hope it is possible from there?).
For accessing both papers' figures you will currently be taken directly
to the journal's copy of these figures. I will try to fix this partly
by the weekend, never mind for the moment, the anonymization is
primarily trying to prevent the authors from finding their papers
being discussed as potentially flawed (those we will discuss in
this regard) at our site :-)
Don't try too hard to find a flaw, if there is one it may not
be possible to find it solely from reading the paper - simply be
critical and fair, and note in your reports what parts of the work
you felt able to "evaluate", and which not (for example, there
may be experimental-methodological insufficiencies that you cannot
know about because you are not an expert; it is perfectly OK to
mention areas which you felt were completely outside your depth
in your report if substantive conclusions were drawn based
on this, e.g. a complicated wet-lab experiment... plus
there is always wikipedia to find out what
a certain technique is used for regularly, of course!)
TIMELINE (see my email message from Friday May 18):
! DEADLINE for submitting ref reports 1 and 2: end of Wed May 30 (new!)
* Thu May 31 BME280B class (12-1:45pm): Discussion Papers 1 and 2
! DEADLINE for submitting ref reports 3 and 4: end of Wed June 6 (adapted DL reflecting that the papers were posted late)
* Thu June 7 BME280B class (12-1:45pm): Discussion Papers 3 and 4
BME280B Pass Requirements (see my email message from Friday May 18):
There will be four papers for which you will hand in one referee
report each (report = fill a form + justify your entries
in a commentary summarizing your opinion/criticism). See above for
deadlines etc. In the two BME280B sessions of Thu May 31 and
Thu June 7, everyone gets to discuss their commentary and defend
their opinions about the papers (two papers in each session).
The class requirement is that you hand in decent referee reports for
all four papers, and participate in both discussion sessions -
(please get in touch asap if you foresee a problem so we can work
out alternative work/timing for you, if necessary).
Presentations
heard earlier in the quarter:
Nested Effects Models for High-Dimensional Phenotyping Screens
The Evolution of Human Diet and Salivary Amylase Genes
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April 19
|
12-1
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Melissa Cline
|
UCSC MCD Biology Department
|
Alternative Splicing and the Human Proteome: Facts and Fallacies
|
April 26
|
12-1
|
Zhefeng Guo
|
UCLA Biological Structures Group
|
Understanding the Structural Basis of Amyloid Fibril Formation
|
May 3
|
12-1
|
Roland Nagel
|
UCSC MCD Biology Department
|
Identification of
Factors that Regulate Muscle-Specific Alternative Splicing in the Mouse
|
May 10
|
12-1
|
Alexander Pisarchik
|
University of Minnesota
|
Protein evolution in the laboratory:
Evolving structure and metal selectivity of an archaeal chelatase
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May 17
|
12-1
|
Sofie Salama
|
UCSC Center for Biomolecular Science & Engineering
|
Characterization of the Function of
Fast Evolving Regions in the Human Genome