UCSC BME 200 Fall 2007

Being a Bioinformatics Grad Student

(Last Update: 12:25 PST 5 December 2007 )
This is a required course for graduate students in bioinformatics.

For catalog copy and pre-requisites, see the main page for BME200.

Who, When, and Where:

Instructor: Kevin Karplus ( karplus@soe.ucsc.edu) http://www.soe.ucsc.edu/~karplus
Office hours: PSB 318, Mon 12:30-1, Wed 4:30-5

lecture and discussion section (REQUIRED): Baskin 156 PSB 305 Tues 4-5:45

Do not take BME 200 for a letter grade!

The lectures and discussions will cover topics specific to bioinformatics, including such things as lab safety and cultural differences between the academic cultures of biology and computer science, as well as more general graduate student stuff, such as how to write a research paper, avoiding sexual harassment, fellowships, library usage, LaTeX, ...

All new grad students should plan on taking 280B this quarter, since it will be a series of introductory lectures by faculty who can accept grad students into their labs for lab rotation projects.

Requirements to pass

There will be a small number of written assignments for this class: a LaTeX exercise, a library/BibTeX exercise, writing a fellowship or grant proposal, and a web page exercise.

The course is graded strictly on the Satisfactory/Unsatisfactory scale. Do not register for a letter grade.

Texts

Required: Optional:

Academic Integrity

Anyone caught cheating in the class will be punished severely—most likely failed in the class and possibly thrown out of grad school.

Cheating includes any attempt to claim someone else's work as your own. Plagiarism in any form (including close paraphrasing) will be considered cheating. Use of any source without proper citation will be considered cheating.

Collaboration without explicit written acknowledgment will be considered cheating. Collaboration on some assignments with explicit written acknowledgment is encouraged—guidelines for the extent of reasonable collaboration will be given in class.

Rogues' Gallery

Who is in the class this year. I'm trying to learn the names of this year's students. I'm hoping to have them all straight within 10 weeks. That doesn't sound very challenging with so few students, but I have real trouble with names. Embarassing admission 1: when I went to put the pictures up on the web, I had lost the sheet with the order of people's names, and I couldn't pair faces with names!

Stephen Benz
Andy Nguyen
Tim Sterne-Weiler
Sam Boyarsky
Herbert Lee
Lauren Lui
James Durbin
Andrew Uzilov
Lee Slater

Tentative schedule of topics

Note: list should be updated throughout the quarter to reflect what really happens.
2 Oct 07
Administrivia.

Presentation by CBSE tech staff on computer and cluster use by bioinformatics grad students. Organization of SoE and bioinformatics file systems. Where things are kept, how to get access to cluster computing. How to report problems (email: cluster-admin) powerpoint presentation

Mailing lists:

compbio
optional mailing list: bioinformatics seminar announcments, jobs, bread-and-tea, ...
compbio is now a mailman-maintained list! See http://www.soe.ucsc.edu/mailman/listinfo/compbio for information about the compbio mailing list.
binf-grads
automatic, can't unsubscribe: official announcements from the department.
grads, grad-news, ...
See the http://www.soe.ucsc.edu/advising/graduate/grademail.html web page for more information about these School of Engineering mailing lists.
genecats
For developers of the genome browser, and comparative genomics research results.
See http://www.soe.ucsc.edu/mailman/listinfo/genecats for information about the genecats mailing list.
netdogs
An informal group of grad students interested in tools for dealing with protein networks.
See http://www.soe.ucsc.edu/mailman/listinfo/netdogs for more information.
mcdseminars
Announcements of the topics for seminars in the Monday+Friday Molecular, Cell, and Developmental Biology series (12:30 in Nat Sci Annex 101) http://lists.pbsci.ucsc.edu/mailman/listinfo/mcdseminars
pdb-l
Users mailing list for the Protein Data Bank. Often has questions about tools and interpretation of protein models, resulting in tutorial replies.
See https://lists.sdsc.edu/mailman/listinfo.cgi/pdb-l for more information.
molvis-list
Molecular visualization mailing list.
See http://bioinformatics.org/mailman/listinfo/molvis-list
bioedu
Bioinformatics education mailing list
See https://bioinformatics.org/mailman/listinfo/bioedu for more information.
BABioinformatics
Bay Area Bioinformatics
http://groups.yahoo.com/group/BABioinformatics/

TA information:

Discussion of Santa Cruz amenities (grocery stores, bike shops, bakeries). Mention of Bike to Work Day (Thurs 4 Oct 2007), Open Studio tours (3 weekends starting 6 Oct 2007), UCSC Farm and Garden fall harvest festival (6 Oct 2007)

MONDAY 8 Oct 07
Not an official class meeting, but there is an NSF fellowship proposal-writing workshop at 4:00-6:00pm in the Muwekma Ohlone Conference Room C, Bay Tree Conference Center. Since you will have to write a fellowship or grant proposal of some sort this quarter, the workshop may well be worth your time.
9 Oct 07
Homework assignment: fellowship application Due Fri 2619 Oct 2007.

Preparing a document with LaTeX. Using a Makefile and gnumake to run LaTeX, BibTeX, dvips, and distill (mentioned, but not gone into detail).
Homework assignment: LaTeX assignment Due 16 Oct 2007.

The purpose of this assignment is to develop some preliminary facility with LaTeX, particularly with math equations and tables. You are to try to duplicate (approximately) the 2-page paper in latex-assign.pdf

There are some examples of a basic LaTeX paper in example.tex and the corresponding output example.pdf. You can use "make" to do the repeated calls to latex with the Makefile

I strongly recommend using LaTeX for thesis proposals and theses. There is a style file available (which I have not checked myself, but which should be a good starting point at least) in http://www.soe.ucsc.edu/~you/notes/ucthesis-ucsc/

Turn in both the .tex source and the printed output by 16 October 2007.

16 Oct 07
Lab safety, Brent Cooley, EHS.
Ergonomics, Kitty Woldow, EHS.

Permissions and user groups. Go through .cshrc file to indicate what things people might want to set up for themselves.

  • Review of LaTeX assignment. The trick for unaligning the first line was rather ugly:
    \begin{eqnarray}
    \hbox to 5pt{$E(c^2) =$ \hskip 0pt minus 1fill} & & \nonumber\\
    	&=& \lambda^{-2} \int_{-\infty}^{\infty}  {y^2\over(1+e^{y})(1+e^{-y})}   dy \\
    
    
    23 Oct 07
    Rita Walker Sexual Harrassment/Title IX.

    Being a TA: Running discussion sections, workload, TA union and strikes. Brief mention of AAUP and their publication Academe, which is available on-line as http://www.aaup.org/publications/Academe/
    Academic integrity: TA responsibilities for detecting, reporting, and enforcing.

    Note: TAs are not allowed to have office hours in shared grad-student space. TA office hours are to be scheduled in Baskin Engineering 314 (scheduler@soe.ucsc.edu handles the scheduling).

    30 Oct 07
    Expectations of a GSR.

    Oral presentation. How to design your slides (Powerpoint, keynote, LaTeX+acroread). How to speak loudly.

    6 Nov 07
    Cultural differences in who is included as co-author on a paper. ... Who is an author?

    Choosing a journal. Open-access or subscriber?

    Pictures in papers: (use epsfig package), examples. Also examples of subfigure package.
    Some discussion of how to produce posters, mainly design and where to print: the School of Engineering poster printer and the Microscopy and Imaging Laboratory in C230 Earth and Marine Sciences http://microscopy.ucsc.edu/ Some discussion of design guidelines.
    BibTeX: citation databases in LaTeX.
    Homework assignment: LaTeX/BibTeX assignment Due 20 Nov 2007.
    Incidentally, it would be a good idea to use the existing database in /projects/compbio/papers/tex/all.bib, by using

    setenv BIBINPUTS .:/projects/compbio/papers/tex::
    
    in your .cshrc file, and saying \bibliography{all,my} to include both your file my.bib and /projects/compbio/papers/tex/all.bib in your search for bibliography entries.
    13 Nov 07
    1. Classroom accomodations for disabilities
      The Dean for Undergraduate Education (William Ladusaw) recommends incorporating the following paragraph into all syllabi: "If you qualify for classroom accommodations because of a disability, please submit your Accommodation Authorization from the Disability Resource Center (DRC) to me during my office hours in a timely manner, preferably within the first two weeks of the quarter. Contact DRC at 459-2089 (voice), 459-4807 (TTY)."

      The DRC has provided an updated and comprehensive faculty resource page at: http://www2.ucsc.edu/drc/faculty_staff/faculty_resources.shtml

    2. Writing proposals (thesis proposals, funding applications, ...) Funding sources.
      Example of a great thesis proposal by Rachel Karchin. (Postscript file Portable Document Format file; both only available from Baskin School of Engineering computers.)
    20 Nov 07
    Setting up a web page, General discussion on presentation of data. Advertising for reading Envisioning Information.

    Homework assignment: Web page assignment Due 4 Dec 07 (last day of class)

    Andy Nguyen pointed out that instructions for setting up Soe web pages, turning on directory indexing, and similar stuff is on the SoE FAQ page: http://www.soe.ucsc.edu/administration/computer/faq/cache/41.html

    27 Nov 07
    Videotaping of short oral presentations.
    4 Dec 07
    Instructor evaluation.

    Critiquing the videotape of presentations (they were all pretty good this year---some of the usual problems of looking at the screen too much and moving head so the microphone did not pick up sound).

    Wed 12 Dec 07 12-3 p.m.
    Final exam slot (not used)
  • Useful resources



    slug icon to go to Scool of Engineering home page
    SoE home
    sketch of Kevin Karplus by Abe
    Kevin Karplus's home page
    BME-slug-icon
    BS, MS, and PhD programs
    BME 205 home page Karplus's lab page UCSC Bioinformatics research

    Questions about page content should be directed to

    Kevin Karplus
    Biomolecular Engineering
    University of California, Santa Cruz
    Santa Cruz, CA 95064
    USA
    karplus@soe.ucsc.edu
    1-831-459-4250
    318 Physical Sciences Building